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In the gastric mucosa, pepsinogen II (PgII) is produced/secreted by glands in the mucus‐secreting antral and cardia compartments, but also by the chief cells and the oxyntic glands. Increasing PgII… Click to show full abstract
In the gastric mucosa, pepsinogen II (PgII) is produced/secreted by glands in the mucus‐secreting antral and cardia compartments, but also by the chief cells and the oxyntic glands. Increasing PgII serum levels are associated with the whole spectrum of gastric inflammatory diseases, including gastritis induced by Helicobacter pylori (H. pylori). This review critically addresses the clinical value of PgII serology for assessing gastric mucosal inflammation, and as a marker of H. pylori status, in both H. pylori‐positive patients and after eradication therapy.
Journal Title: Helicobacter
Year Published: 2022
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