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Liver fluke infection caused by Opisthorchis viverrini is associated with several hepatobiliary diseases including advanced periductal fibrosis (APF) and cholangiocarcinoma. Recently, we demonstrated a persistent APF in over one‐third of… Click to show full abstract
Liver fluke infection caused by Opisthorchis viverrini is associated with several hepatobiliary diseases including advanced periductal fibrosis (APF) and cholangiocarcinoma. Recently, we demonstrated a persistent APF in over one‐third of opisthorchiasis patients after worm removal by praziquantel (PZQ) treatment. However, the underlying mechanism(s) of this phenomena is unclear. Given a co‐infection with Helicobacter pylori (H. pylori) especially cagA‐positive strain enhances APF, we hypothesized that H. pylori with CagA virulent factor contributes to persistent APF.
Journal Title: Helicobacter
Year Published: 2022
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