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Hepatitis C virus core protein increases Snail expression and induces epithelial–mesenchymal transition through the signal transducer and activator of transcription 3 pathway in hepatoma cells

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Aberrant expression of Snail, a mediator of epithelial–mesenchymal transition (EMT), is crucial for cancer invasiveness and metastasis. Although hepatitis C virus (HCV) core protein has been implicated in hepatocarcinogenesis, the… Click to show full abstract

Aberrant expression of Snail, a mediator of epithelial–mesenchymal transition (EMT), is crucial for cancer invasiveness and metastasis. Although hepatitis C virus (HCV) core protein has been implicated in hepatocarcinogenesis, the relationship between HCV core and Snail expression has not been clarified.

Keywords: mesenchymal transition; core protein; epithelial mesenchymal; expression; hepatitis virus; core

Journal Title: Hepatology Research
Year Published: 2017

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