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Low‐density lipoprotein receptor knockout (LDLR‐KO) mice fed a modified choline‐deficient and amino acid‐defined (mCDAA) diet show non‐alcoholic steatohepatitis (NASH)‐like pathophysiology. In order to pharmacologically benchmark this model, effects of pioglitazone… Click to show full abstract
Low‐density lipoprotein receptor knockout (LDLR‐KO) mice fed a modified choline‐deficient and amino acid‐defined (mCDAA) diet show non‐alcoholic steatohepatitis (NASH)‐like pathophysiology. In order to pharmacologically benchmark this model, effects of pioglitazone (a thiazolidinedione) and candesartan cilexetil (an angiotensin II type 1 receptor blocker) on steatosis and liver fibrosis were examined.
Keywords:
density lipoprotein;
low density;
receptor;
modified choline;
lipoprotein receptor;
receptor knockout
Journal Title: Hepatology Research
Year Published: 2017
Link to full text (if available)
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Journal Title: Hepatology Research
Year Published: 2017
Link to full text (if available)
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recommendations!