Fetal hepatic stem/progenitor cells, called hepatoblasts, play central roles in liver organogenesis; however, molecular mechanisms regulating proliferation and terminal differentiation of such cells have not been completely elucidated. Bone morphogenetic… Click to show full abstract
Fetal hepatic stem/progenitor cells, called hepatoblasts, play central roles in liver organogenesis; however, molecular mechanisms regulating proliferation and terminal differentiation of such cells have not been completely elucidated. Bone morphogenetic protein‐4 (BMP‐4) is essential for the development of stem cells in various tissues, but its function in regulating the phenotype of hepatoblasts after the mid‐gestational fetal stage remains unclear. The aim of this study is to clarify a functional role for BMP‐4 in proliferation and terminal differentiation of murine hepatoblasts in mid‐gestational fetal livers.
Journal Title: Hepatology Research
Year Published: 2017
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