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Genetic variant in DICER gene is associated with prognosis of hepatocellular carcinoma in a Chinese cohort

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MicroRNAs (miRNAs) function as gene regulators and play crucial roles in the pathogenesis and prognosis of hepatocellular carcinoma (HCC). Genetic variants in miRNA processing genes may affect miRNA expression and… Click to show full abstract

MicroRNAs (miRNAs) function as gene regulators and play crucial roles in the pathogenesis and prognosis of hepatocellular carcinoma (HCC). Genetic variants in miRNA processing genes may affect miRNA expression and contribute to HCC risk and survival. We hypothesized that single nucleotide polymorphisms (SNPs) in miRNA processing genes may be associated with HCC susceptibility and prognosis. The study aims to verify whether this hypothesis is right or not.

Keywords: hepatocellular carcinoma; prognosis; prognosis hepatocellular; genetic variant; gene

Journal Title: Hepatology Research
Year Published: 2017

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