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Higher efficacy of pegylated interferon‐α2b add‐on therapy in hepatitis B envelope antigen‐positive chronic hepatitis B patients on tenofovir monotherapy

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Monotherapy with pegylated interferon‐α (Peg‐IFNα) or the nucleos(t)ide analogs (NA) currently approved for treating chronic hepatitis B (CHB) has limited efficacy. Studies on the combination of Peg‐IFNα/NA have shown conflicting… Click to show full abstract

Monotherapy with pegylated interferon‐α (Peg‐IFNα) or the nucleos(t)ide analogs (NA) currently approved for treating chronic hepatitis B (CHB) has limited efficacy. Studies on the combination of Peg‐IFNα/NA have shown conflicting results. We investigated whether sequentially adding on Peg‐IFNα to tenofovir enhances serological response rates.

Keywords: chronic hepatitis; hepatitis; pegylated interferon; efficacy; monotherapy; peg ifn

Journal Title: Hepatology Research
Year Published: 2018

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