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Homocysteine supplementation ameliorates steatohepatitis induced by a choline‐deficient diet in mice

High concentrations of homocysteine are believed to induce lipid synthesis and cell injury through endoplasmic reticulum (ER) stress in metabolic syndrome. However, homocysteine could be used to improve steatohepatitis induced… Click to show full abstract

High concentrations of homocysteine are believed to induce lipid synthesis and cell injury through endoplasmic reticulum (ER) stress in metabolic syndrome. However, homocysteine could be used to improve steatohepatitis induced by choline deficiency, in which methyl donors are decreased. The aim of the present study was to clarify the role of the physiological concentration of homocysteine in the development of steatohepatitis induced by choline deficiency.

Keywords: supplementation ameliorates; steatohepatitis induced; induced choline; homocysteine supplementation; ameliorates steatohepatitis

Journal Title: Hepatology Research
Year Published: 2019

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