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Rho‐kinase (ROCK) inhibitor could ameliorate liver fibrosis by suppressing hepatic stellate cell (HSC) activation. However, because systemic administration of ROCK inhibitor causes serious adverse effects, we developed a drug delivery… Click to show full abstract
Rho‐kinase (ROCK) inhibitor could ameliorate liver fibrosis by suppressing hepatic stellate cell (HSC) activation. However, because systemic administration of ROCK inhibitor causes serious adverse effects, we developed a drug delivery system selectively delivering ROCK inhibitor to HSCs. Here, we examined whether our developed vitamin A (VA)‐coupled liposomal ROCK inhibitor reduced liver fibrosis in rats without causing systemic adverse effects.
Keywords:
inhibitor;
rock inhibitor;
liver fibrosis;
adverse effects;
rho kinase
Journal Title: Hepatology Research
Year Published: 2019
Link to full text (if available)
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Journal Title: Hepatology Research
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!