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Blocking development of liver fibrosis augments hepatic progenitor cell‐derived liver regeneration in a mouse chronic liver injury model

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The roles of hepatic progenitor cells (HPCs) in regeneration of a diseased liver are unclear. Hepatic stellate cells (HSCs) contribute to liver fibrosis but are also a component of the… Click to show full abstract

The roles of hepatic progenitor cells (HPCs) in regeneration of a diseased liver are unclear. Hepatic stellate cells (HSCs) contribute to liver fibrosis but are also a component of the HPC niche. Hepatic progenitor cells expand along with HSC activation and liver fibrosis. However, little is known about the interplay of liver fibrosis and HPC‐mediated liver regeneration. This study aimed to investigate HSCs and HPCs in liver regeneration.

Keywords: liver regeneration; regeneration; hepatic progenitor; liver fibrosis

Journal Title: Hepatology Research
Year Published: 2019

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