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Association of proteinuria with improved prognosis in unresectable hepatocellular carcinoma treated with atezolizumab and bevacizumab, and the predictive role of serum vascular endothelial growth factor D levels: A multicenter retrospective study

Atezolizumab/bevacizumab is a first‐line therapy for unresectable hepatocellular carcinoma (HCC). Among several adverse events, grade ≥2 proteinuria is considered a significant adverse event that may cause bevacizumab interruption. Studies have… Click to show full abstract

Atezolizumab/bevacizumab is a first‐line therapy for unresectable hepatocellular carcinoma (HCC). Among several adverse events, grade ≥2 proteinuria is considered a significant adverse event that may cause bevacizumab interruption. Studies have shown that proteinuria might predict improved prognosis, although data are scarce and the association remains controversial, and the mechanisms and predictive factors remain unclear. We aimed to clarify these.

Keywords: unresectable hepatocellular; hepatocellular carcinoma; bevacizumab; improved prognosis; atezolizumab bevacizumab

Journal Title: Hepatology Research
Year Published: 2024

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