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Prognostic stratification of oestrogen receptor‐positive HER2‐negative lymph node‐negative class of breast cancer

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Multigene assay is recommended currently for prognostic stratification of the clinically indeterminate group of breast cancer (BC) patients defined as lymph node (LN)‐negative, oestrogen receptor (ER)‐positive, HER2‐negative (LN−/ER+/HER2−) to determine… Click to show full abstract

Multigene assay is recommended currently for prognostic stratification of the clinically indeterminate group of breast cancer (BC) patients defined as lymph node (LN)‐negative, oestrogen receptor (ER)‐positive, HER2‐negative (LN−/ER+/HER2−) to determine the use of chemotherapy. However, this cohort, comprising approximately 40% of BC, is not a homogeneous group and shows variable outcome. This study aims to determine the prognostic value of routinely assessed variables, singly and in combination, in LN−/ER+/HER2− BC patients.

Keywords: prognostic stratification; breast cancer; node negative; lymph node; her2; oestrogen receptor

Journal Title: Histopathology
Year Published: 2017

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