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Acute leukaemia with a pure erythroid phenotype: under‐recognized morphological and cytogenetic signatures associated universally with primary refractory disease and a dismal clinical outcome

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Pure erythroid leukaemia (PEL) is an extremely rare and aggressive subtype of acute myeloid leukaemia defined by the World Health Organization (WHO) as a neoplastic proliferation of immature cells committed… Click to show full abstract

Pure erythroid leukaemia (PEL) is an extremely rare and aggressive subtype of acute myeloid leukaemia defined by the World Health Organization (WHO) as a neoplastic proliferation of immature cells committed exclusively to the erythroid lineage, comprising >80% of bone marrow cells and not meeting the criteria of other well‐defined myeloid neoplasms. The aim of this study was to describe the clinicopathological features of acute leukaemias with a pure erythroid phenotype (ALPEP) irrespective of their WHO classification and to determine if ALPEP represents a distinct clinicopathological entity.

Keywords: pure erythroid; acute leukaemia; pure; erythroid phenotype

Journal Title: Histopathology
Year Published: 2017

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