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Accurate classification of salivary gland neoplasms may be challenging, owing to morphological overlap, particularly in small biopsies. Recurrent translocations involving the high‐mobility group AT‐hook 2 (HMGA2) gene are present in… Click to show full abstract
Accurate classification of salivary gland neoplasms may be challenging, owing to morphological overlap, particularly in small biopsies. Recurrent translocations involving the high‐mobility group AT‐hook 2 (HMGA2) gene are present in a subset of pleomorphic adenomas (PAs) and carcinoma ex‐pleomorphic adenomas (CA ex‐PAs). The aim of this study was to evaluate immunohistochemical HMGA2 expression in 225 salivary gland tumours, including 56 PAs, 37 CA ex‐PAs, and 132 potential histological mimics, to determine its diagnostic utility.
Journal Title: Histopathology
Year Published: 2017
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