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PHOX2B reliably distinguishes neuroblastoma among small round blue cell tumours

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Neuroblastoma shows considerable histological overlap with other small round blue cell tumours. PHOX2B, a transcription factor that is essential for autonomic nervous system development, has been reported as an immunohistochemical… Click to show full abstract

Neuroblastoma shows considerable histological overlap with other small round blue cell tumours. PHOX2B, a transcription factor that is essential for autonomic nervous system development, has been reported as an immunohistochemical marker for neuroblastoma. The aim of this study was to validate the specificity and diagnostic utility of PHOX2B for peripheral neuroblastic tumours.

Keywords: round blue; blue cell; neuroblastoma; small round; cell tumours

Journal Title: Histopathology
Year Published: 2017

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