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A rare case of a solitary fibrous tumour of bone showing NAB2–STAT6 exon 3–exon 19 fusion

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a solitary fibrous tumour (SFT) is a mesenchymal tumour of fibroblastic origin that invariably displays a prominent hemangiopericytoma (HPC)-like vasculature. Currently, hemangiopericytoma (HPC) of soft tissues is a disregarded entity… Click to show full abstract

a solitary fibrous tumour (SFT) is a mesenchymal tumour of fibroblastic origin that invariably displays a prominent hemangiopericytoma (HPC)-like vasculature. Currently, hemangiopericytoma (HPC) of soft tissues is a disregarded entity and is rather considered as a growth pattern, more often seen in tumours such as synovial sarcomas, malignant peripheral nerve sheath tumours, myopericytomas and SFTs. In most SFTs, tumour cells are CD34 immunopositive.1-2 Lately, signal transducer and activator of transcription (STAT)6 has been identified as a highly sensitive and specific immunohistochemical (IHC) marker for diagnosing a SFT, and a surrogate for a specific fusion gene, NAB2-STAT6, characterizing most SFTs. This article is protected by copyright. All rights reserved.

Keywords: solitary fibrous; fibrous tumour; fusion; nab2 stat6; tumour

Journal Title: Histopathology
Year Published: 2018

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