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Infantile fibrosarcoma is characterised by intersecting fascicles of spindle cells and ETV6–NTRK3 gene fusion in most cases. Given histological overlap with other spindle‐cell tumours, the diagnosis can be challenging and… Click to show full abstract
Infantile fibrosarcoma is characterised by intersecting fascicles of spindle cells and ETV6–NTRK3 gene fusion in most cases. Given histological overlap with other spindle‐cell tumours, the diagnosis can be challenging and often requires molecular confirmation. A recently developed pan‐TRK antibody shows promise for identifying tumours with NTRK fusions. The purpose of this study was to evaluate the potential diagnostic utility of pan‐TRK immunohistochemistry for infantile fibrosarcoma.
Keywords:
pan trk;
trk immunohistochemistry;
immunohistochemistry infantile;
infantile fibrosarcoma
Journal Title: Histopathology
Year Published: 2018
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Journal Title: Histopathology
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!