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The histological diagnosis of IgG4‐related disease on small biopsies: challenges and pitfalls

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The pathological diagnosis of IgG4‐related disease (IgG4‐RD) relies on histology, IgG4‐positive cells, and an increased IgG4/IgG ratio. Small biopsies from patients with a presumptive diagnosis of IgG4‐RD often fail to… Click to show full abstract

The pathological diagnosis of IgG4‐related disease (IgG4‐RD) relies on histology, IgG4‐positive cells, and an increased IgG4/IgG ratio. Small biopsies from patients with a presumptive diagnosis of IgG4‐RD often fail to meet consensus histological criteria. The aims of this study were to evaluate consecutive small biopsies from patients with a presumptive diagnosis of IgG4‐RD, and to assess the significance of the pathological findings.

Keywords: igg4; related disease; small biopsies; diagnosis igg4; igg4 related

Journal Title: Histopathology
Year Published: 2019

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