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Loss of expression of MLH1 in non‐dysplastic crypts is a harbinger of neoplastic progression in sessile serrated adenomas/polyps

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Dysplasia in colonic sessile serrated adenomas (SSAs)/sessile serrated polyps often shows loss of MLH1 expression as determined with immunohistochemistry, but the significance of loss of MLH1 expression in non‐dysplastic crypts… Click to show full abstract

Dysplasia in colonic sessile serrated adenomas (SSAs)/sessile serrated polyps often shows loss of MLH1 expression as determined with immunohistochemistry, but the significance of loss of MLH1 expression in non‐dysplastic crypts in these polyps is less well studied. The purpose of this study was to evaluate the prevalence of loss of MLH1 expression in non‐dysplastic crypts in SSAs, and to evaluate its significance with regard to progression of these polyps.

Keywords: mlh1; non dysplastic; expression; sessile serrated; dysplastic crypts; loss

Journal Title: Histopathology
Year Published: 2019

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