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Distinct genetic alterations and luminal molecular subtype in nested variant of urothelial carcinoma

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Nested variant of urothelial carcinoma (NVUC) is rare, and only a few small series exist. Molecular characteristics and the classifying marker profile as well as therapeutic targets of this specific… Click to show full abstract

Nested variant of urothelial carcinoma (NVUC) is rare, and only a few small series exist. Molecular characteristics and the classifying marker profile as well as therapeutic targets of this specific variant are mostly unknown. The aim of this study was to characterise NVUC at the molecular level in one of the largest cohorts to date. In addition, we applied an immunohistochemical marker panel in order to define the molecular subtype.

Keywords: molecular subtype; variant urothelial; nested variant; urothelial carcinoma

Journal Title: Histopathology
Year Published: 2019

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