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Poorly differentiated neuroendocrine carcinoma of the head and neck: human papillomavirus tumour status/p16 status and impact on overall survival

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Poorly differentiated neuroendocrine carcinoma (PDNEC) of the head and neck is a rare high‐grade neuroendocrine neoplasm. Human papillomavirus (HPV) status and p16 status are as yet unclear among PDNECs, owing… Click to show full abstract

Poorly differentiated neuroendocrine carcinoma (PDNEC) of the head and neck is a rare high‐grade neuroendocrine neoplasm. Human papillomavirus (HPV) status and p16 status are as yet unclear among PDNECs, owing to a lack of statistical analysis. The objective of the present study was therefore to evaluate their potential clinicopathological associations, and their prognostic impact on overall survival in PDNECs of the head and neck, regardless to HPV genotype.

Keywords: status; poorly differentiated; head neck; differentiated neuroendocrine

Journal Title: Histopathology
Year Published: 2019

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