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The role of cyclin D1 and Ki‐67 in the development and prognostication of thin melanoma

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Despite their low individual metastatic potential, thin melanomas (≤1 mm Breslow thickness) contribute significantly to melanoma mortality overall. Therefore, identification of prognostic biomarkers is particularly important in this subgroup of… Click to show full abstract

Despite their low individual metastatic potential, thin melanomas (≤1 mm Breslow thickness) contribute significantly to melanoma mortality overall. Therefore, identification of prognostic biomarkers is particularly important in this subgroup of melanoma. Prompted by preclinical results, we investigated cyclin D1 protein and Ki‐67 expression in in‐situ, metastatic and non‐metastatic thin melanomas.

Keywords: melanoma; thin melanoma; development prognostication; role cyclin; cyclin development; prognostication thin

Journal Title: Histopathology
Year Published: 2020

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