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Automated assessment of Ki‐67 in breast cancer: the utility of digital image analysis using virtual triple staining and whole slide imaging

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Precise evaluation of proliferative activity is essential for the stratified treatment of luminal‐type breast cancer (BC). Immunohistochemical staining of Ki‐67 has been widely used to determine proliferative activity and is… Click to show full abstract

Precise evaluation of proliferative activity is essential for the stratified treatment of luminal‐type breast cancer (BC). Immunohistochemical staining of Ki‐67 has been widely used to determine proliferative activity and is recognised to be a useful prognostic marker. However, there remains discussion concerning the methodology. We aimed to develop an automated and reliable Ki‐67 assessment approach for invasive BC.

Keywords: breast; automated assessment; cancer utility; assessment breast; breast cancer

Journal Title: Histopathology
Year Published: 2020

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