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Complete loss of histone H3 lysine 27 trimethylation (H3K27me3) has recently emerged as a biomarker for malignant peripheral nerve sheath tumours (MPNST). Loss of H3K27me3 staining has also been reported… Click to show full abstract
Complete loss of histone H3 lysine 27 trimethylation (H3K27me3) has recently emerged as a biomarker for malignant peripheral nerve sheath tumours (MPNST). Loss of H3K27me3 staining has also been reported in post‐radiation MPNST; however, it has not been evaluated in a large series of radiation‐associated sarcomas of different histological subtypes. The aim of this study was to assess H3K27me3 labelling by immunohistochemistry in radiation‐associated sarcomas and to determine the prevalence of H3K27me3 loss in these tumours.
Journal Title: Histopathology
Year Published: 2020
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