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Esophageal post-Therapy Myeloid Sarcoma masquerading as Poorly Differentiated Adenocarcinoma: A Diagnostic Pitfall.

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A 73-year-old male with complaints of dysphagia, fatigue and weight loss for the past one year underwent an upper gastrointestinal endoscopy, depicting a partially obstructing mass in the lower third… Click to show full abstract

A 73-year-old male with complaints of dysphagia, fatigue and weight loss for the past one year underwent an upper gastrointestinal endoscopy, depicting a partially obstructing mass in the lower third of esophagus. An endoscopic ultrasound showed a hypoechoic mass with suggested invasion into the muscularis propria with two enlarged level 8 paraesophageal lymph nodes. By sonographic criteria, the tumor was staged as T3N1. Multiple biopsies confirmed poorly differentiated adenocarcinoma (cytokeratin positive) with gland formation (<50% of tumor) and with focal signet ring cells and some extracellular mucin (Figure 1A).

Keywords: poorly differentiated; esophageal post; post therapy; therapy myeloid; differentiated adenocarcinoma

Journal Title: Histopathology
Year Published: 2021

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