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Mismatch repair (MMR) deficiency is commonly caused by functional inactivation of MLH1, PMS2, MSH2 or MSH6. The morphological and molecular correlates of MMR deficiency have been extensively characterized in certain… Click to show full abstract
Mismatch repair (MMR) deficiency is commonly caused by functional inactivation of MLH1, PMS2, MSH2 or MSH6. The morphological and molecular correlates of MMR deficiency have been extensively characterized in certain tumour types such as colorectal and endometrial adenocarcinoma. In contrast, the histological and molecular features of MMR‐deficient prostate cancer remain incompletely described. In this study, we evaluated 19 MMR‐deficient prostate cancers, including 11 cases without prior systemic treatment.
Journal Title: Histopathology
Year Published: 2022
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