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Deep‐learning‐based classification of desmoplastic reaction on H&E predicts poor prognosis in oesophageal squamous cell carcinoma

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Desmoplastic reaction (DR) categorisation has been shown to be a promising prognostic factor in oesophageal squamous cell carcinoma (ESCC). The usual DR evaluation is performed using semiquantitative scores, which can… Click to show full abstract

Desmoplastic reaction (DR) categorisation has been shown to be a promising prognostic factor in oesophageal squamous cell carcinoma (ESCC). The usual DR evaluation is performed using semiquantitative scores, which can be subjective. This study aimed to investigate whether a deep‐learning classifier could be used for DR classification. We further assessed the prognostic significance of the deep‐learning classifier and compared it to that of manual DR reporting and other pathological factors currently used in the clinic.

Keywords: cell carcinoma; oesophageal squamous; squamous cell; desmoplastic reaction; deep learning

Journal Title: Histopathology
Year Published: 2022

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