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Pleomorphic xanthoastrocytoma (PXA) is a rare circumscribed glioma, characterized by frequent BRAF p. V600E mutation, and classified as grade 2 or 3. Owing to overlapping clinical–pathological features, the histological distinction… Click to show full abstract
Pleomorphic xanthoastrocytoma (PXA) is a rare circumscribed glioma, characterized by frequent BRAF p. V600E mutation, and classified as grade 2 or 3. Owing to overlapping clinical–pathological features, the histological distinction from glioblastoma (GBM) with giant cells (GCs) is challenging. Based on the high frequency of TP53 and RB1 alterations in the latter, this study aimed to assess the value of BRAF, p53, and pRB immunostainings in the differential diagnosis.
Keywords:
giant cells;
glioblastoma;
differential diagnosis;
pleomorphic xanthoastrocytoma
Journal Title: Histopathology
Year Published: 2022
Link to full text (if available)
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Journal Title: Histopathology
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!