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Defining an abnormal p53 immunohistochemical stain in Barrett's oesophagus‐related dysplasia: a single‐positive crypt is a sensitive and specific marker of dysplasia

p53 is an independent risk stratification marker in Barrett's oesophagus (BE), but no universally accepted definition exists for abnormal p53 staining. Herein, we assess p53 stains in two cohorts to:… Click to show full abstract

p53 is an independent risk stratification marker in Barrett's oesophagus (BE), but no universally accepted definition exists for abnormal p53 staining. Herein, we assess p53 stains in two cohorts to: (1) define abnormal p53 staining in BE‐related dysplasia (BERD) and (2) assess the specificity and sensitivity of this cut‐point for the diagnosis of dysplasia.

Keywords: marker; related dysplasia; dysplasia; abnormal p53; p53; barrett oesophagus

Journal Title: Histopathology
Year Published: 2022

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