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Molecular correlates of invasion pattern in HPV‐associated endocervical adenocarcinoma: emergence of two distinct risk‐stratified tiers

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The pattern‐based (Silva) classification of invasive human papilloma virus (HPV)‐associated endocervical adenocarcinomas (HPVA) is an established and reproducible method to predict outcomes for this otherwise stage‐dependent group of tumours. Previous… Click to show full abstract

The pattern‐based (Silva) classification of invasive human papilloma virus (HPV)‐associated endocervical adenocarcinomas (HPVA) is an established and reproducible method to predict outcomes for this otherwise stage‐dependent group of tumours. Previous studies utilising targeted sequencing have shown a correlation between mutational profiles and an invasive pattern. However, such correlation has not been explored using comprehensive molecular testing.

Keywords: invasion pattern; molecular correlates; associated endocervical; hpv associated; correlates invasion

Journal Title: Histopathology
Year Published: 2023

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