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Paratesticular/inguinal SMARCB1/INI1 deficient carcinomas with yolk sac tumour‐like differentiation are aggressive somatic malignancies

Extragonadal yolk sac tumour (YST) is rare, and may present a diagnostic challenge. YST differentiation was recently reported in some somatically derived tumours in the sinonasal location and in the… Click to show full abstract

Extragonadal yolk sac tumour (YST) is rare, and may present a diagnostic challenge. YST differentiation was recently reported in some somatically derived tumours in the sinonasal location and in the female genital tract, together with a SMARCB1/INI1 loss. We report two paratesticular/inguinal tumours with striking morphological and immunohistochemical similarities with YST, further expanding the spectrum of extragonadal tumours with YST‐like morphology and SMARCB1/INI1 loss.

Keywords: differentiation; paratesticular inguinal; smarcb1 ini1; yolk sac; sac tumour

Journal Title: Histopathology
Year Published: 2025

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