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Improved stability and skin penetration through glycethosomes loaded with glycyrrhetinic acid

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In recent years, glycyrrhetinic acid (GA) has been popularly used in cosmetics because of its anti‐inflammatory and anti‐oxidant effects. However, due to the poor water solubility of GA and the… Click to show full abstract

In recent years, glycyrrhetinic acid (GA) has been popularly used in cosmetics because of its anti‐inflammatory and anti‐oxidant effects. However, due to the poor water solubility of GA and the barrier effect of human skin, the penetration of GA through the skin may be hindered. Liposomes are a common delivery system for functional compounds in cosmetics. Nonetheless, the stability and transdermal effect of traditional liposomes are limited. The aim of this work was to prepare a new liposome system that contained glycerol and ethanol to enhance the stability of the vesicles and promote the penetration of GA into the skin.

Keywords: skin; improved stability; penetration; glycyrrhetinic acid; skin penetration

Journal Title: International Journal of Cosmetic Science
Year Published: 2022

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