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Oleracone C from Portulaca oleracea attenuates UVB‐induced changes in matrix metalloproteinase and type I procollagen production via MAPK and TGF‐β/Smad pathways in human keratinocytes

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Chronic exposure to ultraviolet (UV) radiation induces photo‐oxidation, which in turn causes the overproduction of matrix metalloproteinases (MMPs) and collagen degradation. These symptoms are referred to as photoaging, which is… Click to show full abstract

Chronic exposure to ultraviolet (UV) radiation induces photo‐oxidation, which in turn causes the overproduction of matrix metalloproteinases (MMPs) and collagen degradation. These symptoms are referred to as photoaging, which is characterized by skin thickness, irregular pigmentation, elastosis and coarse wrinkles. In this study, the protective effects of oleracone C isolated from Portulaca olerace against UVB‐induced changes in MMPs and type I procollagen production were investigated in human keratinocytes.

Keywords: induced changes; human keratinocytes; uvb induced; type procollagen; procollagen production

Journal Title: International Journal of Cosmetic Science
Year Published: 2022

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