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Non‐Healing Nasolabial Ulcerated Plaque: A Clinicopathologic Challenge

A 66‐year‐old male with a history of chronic epistaxis and sinusitis presented with a non‐healing ulcer on the right nasolabial region persisting for 7 months. While denying additional symptoms, he admitted… Click to show full abstract

A 66‐year‐old male with a history of chronic epistaxis and sinusitis presented with a non‐healing ulcer on the right nasolabial region persisting for 7 months. While denying additional symptoms, he admitted to recreational cocaine smoking. Examination revealed an ulcerated plaque with raised, pink‐edged borders extending from the right nasal rim to the upper lip. A thorough diagnostic workup was unremarkable, although wound cultures identified growth of Pseudomonas aeruginosa and Staphylococcus aureus. Despite a year‐long trial of antibiotics, the ulcer remained resistant to treatment. Biopsy findings included pseudoepitheliomatous hyperplasia with a dense dermal plasmocytic infiltrate and scattered eosinophils. A 6‐week course of oral steroids achieved rapid and significant clinical improvement, though the lesion recurred following steroid tapering below 5 mg daily.

Keywords: nasolabial ulcerated; non healing; ulcerated plaque; healing nasolabial; plaque clinicopathologic

Journal Title: International Journal of Dermatology
Year Published: 2025

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