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Nomenclature for factors of the HLA system, update January, February and March 2019

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The following sequences have been submitted to the Nomenclature Committee since the October, November and December 2018 no‐ menclature update Marsh (2019) and, following agreed policy, have been assigned official… Click to show full abstract

The following sequences have been submitted to the Nomenclature Committee since the October, November and December 2018 no‐ menclature update Marsh (2019) and, following agreed policy, have been assigned official allele designations Marsh et al. (2010). Full de‐ tails of all sequences will be published in a forthcoming report. Below are listed the newly assigned sequences (Table 1) and con‐ firmations of previously reported sequences (Table 2). The accession number of each sequence is given, and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case, you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publi‐ cations that describe new HLA sequences is given in Table 3. In ad‐ dition, the sequence for C*02:02:05 was extended and shown to be a silent variant of C*02:10:01:01, as a result, it has been renamed C*02:10:06 and the name C*02:02:05 has been abandoned. The al‐ leles A*02:795 and A*01:281 were shown to have a nonsynonymous change to their start codon which may affect protein expression; as a result, the Q suffix was added to their allele names. All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IPD‐IMGT/HLA Database using the sequence submission tool provided Robinson et al. (2015). The IPD‐IMGT/ HLA database may be accessed via the World Wide Web at www. ebi.ac.uk/ipd/imgt/hla

Keywords: factors hla; hla system; ipd imgt; imgt hla; sequence

Journal Title: International Journal of Immunogenetics
Year Published: 2019

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