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Allelic and haplotypic data of MHC class II Alu insertions in Ngazidja (Comoros archipelago) and insight on its historical biology

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This study aimed to analyse, for the first time, five MHC class II polymorphic Alu insertions in a population with a strong Sub‐Saharan African genetic background: the Ngazidja islanders and… Click to show full abstract

This study aimed to analyse, for the first time, five MHC class II polymorphic Alu insertions in a population with a strong Sub‐Saharan African genetic background: the Ngazidja islanders and compare its allelic and haplotypic data with Worldwide populations. The genotyping was performed in 80 individuals, using simple PCR and agarose gel electrophoresis methods. Allele and haplotype frequencies, genetic diversity, Hardy–Weinberg equilibrium deviations, normalized deviate of homozygotes and pairwise linkage disequilibrium were estimated. The phylogenetic analyses included the available population data.

Keywords: mhc class; haplotypic data; allelic haplotypic; alu insertions; biology

Journal Title: International Journal of Immunogenetics
Year Published: 2022

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