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The translocation t(12;21)(p13;q22) resulting in the fusion gene ETV6–RUNX1, is the most frequent gene fusion in childhood B lymphoblastic leukemia. In the Nordic Society of Paediatric Haematology and Oncology ALL‐2008… Click to show full abstract
The translocation t(12;21)(p13;q22) resulting in the fusion gene ETV6–RUNX1, is the most frequent gene fusion in childhood B lymphoblastic leukemia. In the Nordic Society of Paediatric Haematology and Oncology ALL‐2008 treatment protocol, treatment stratification in B‐lineage ALL is based on results of minimal residual disease (MRD) analysis with fluorescence‐activated cell sorting (FACS). In this study, we determined whether RT‐qPCR of the ETV6–RUNX1 fusion transcript can be a reliable alternative for MRD analysis.
Journal Title: International Journal of Laboratory Hematology
Year Published: 2017
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