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Exploiting adaptive immune receptor recombination read recoveries from exome files to identify subsets of ALL and to establish TCR features that correlate with better outcomes

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The recovery of adaptive immune receptor (IR) recombination reads from tumour‐derived genomics files has advanced the understanding of the immune system's interaction with cancer. This approach has been largely limited… Click to show full abstract

The recovery of adaptive immune receptor (IR) recombination reads from tumour‐derived genomics files has advanced the understanding of the immune system's interaction with cancer. This approach has been largely limited to solid tumours, where genomics file preparation allows for the recovery of adaptive IR reads corresponding to the T‐cells and B‐cells found in the solid tumour microenvironment. In this study, we sought to determine whether IR recombination reads from liquid tumour genomics files could also be informative.

Keywords: exploiting adaptive; recombination; immune receptor; adaptive immune; receptor recombination

Journal Title: International Journal of Laboratory Hematology
Year Published: 2022

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