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Independent prognostic significance of TP53 mutations in adult acute myeloid leukaemia with complex karyotype

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Adult acute myeloid leukaemia (AML) patients with complex karyotype (CK) generally have unfavourable outcomes. CK commonly co‐exists with characteristic chromosomal and genetic abnormalities such as monosomal karyotype (MK), −17 or… Click to show full abstract

Adult acute myeloid leukaemia (AML) patients with complex karyotype (CK) generally have unfavourable outcomes. CK commonly co‐exists with characteristic chromosomal and genetic abnormalities such as monosomal karyotype (MK), −17 or 17p‐ [abn(17p)] and TP53 mutations. Their individual prognostic significance needs to be clarified.

Keywords: complex karyotype; tp53 mutations; prognostic significance; acute myeloid; myeloid leukaemia; adult acute

Journal Title: International Journal of Laboratory Hematology
Year Published: 2022

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