An extraordinary recent study by Enamorado et al . 1 has, for the first time, demonstrated that immunity to the microbiota enhances repair of sensory nerves and epithelial tissues within… Click to show full abstract
An extraordinary recent study by Enamorado et al . 1 has, for the first time, demonstrated that immunity to the microbiota enhances repair of sensory nerves and epithelial tissues within the skin. Colonization of the skin by Staphylococcus aureus (SA) generated commensal-specific interleukin (IL)-17 – producing CD4 + T helper 17 (Th17) cells that accelerated repair of cutaneous nerve fibers and restored normal sensory thresholds. Remarkably, this “type 17 immunity” evoked minimal inflammation or pain and had no detrimental effect on host immunity to further infections by different SA strains.
Journal Title: Immunology and Cell Biology
Year Published: 2023
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