LAUSR

Dear Editors, We read the article by Ozer Balin et al with interest and would like to comment on the results, focusing on data expression and statistical evaluation regarding serum pentraxin-3 (PTX3) levels. PTX3, a soluble pattern recognition receptor, is an acute-phase protein, and its level in systemic circulation was proposed as a marker for the prediction and/or prognostication of cardiovascular, metabolic, infectious, and inflammatory disorders as in the present study. As in the case of C-reactive protein (CRP), distribution of serum PTX3 is skewed to the right (positive skewness) in healthy population, but unlike CRP, it may increase by up to 1000 to 10 000 times in case of disease, and its range