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Potentiation of antibiotic against Pseudomonas aeruginosa biofilm: a study with plumbagin and gentamicin

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Pseudomonas aeruginosa is one of the fatal biofilm‐forming pathogens which pose to be a problem in clinical infections, contamination of food and marine ecosystems. In this report, a naphthoquinone–plumbagin has… Click to show full abstract

Pseudomonas aeruginosa is one of the fatal biofilm‐forming pathogens which pose to be a problem in clinical infections, contamination of food and marine ecosystems. In this report, a naphthoquinone–plumbagin has been explored for its antimicrobial (antibacterial and antibiofilm) activity against P. aeruginosa biofilm. The ability of plumbagin to enhance the bioactivity of a known broad‐spectrum antibiotic was further assayed by combining the sub‐MIC doses of plumbagin with sub‐MIC doses of gentamicin against P. aeruginosa biofilm.

Keywords: pseudomonas aeruginosa; antibiotic pseudomonas; plumbagin; biofilm; aeruginosa biofilm; potentiation antibiotic

Journal Title: Journal of Applied Microbiology
Year Published: 2017

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