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Antibacterial and antibiofilm activities of thiazolidine‐2,4‐dione and 4‐thioxo‐thiazolidin‐2‐one derivatives against multidrug‐resistant Staphylococcus aureus clinical isolates

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Antimicrobial resistance is one of the highest priorities in global public health with Staphylococcus aureus among the most important microorganisms due to its rapidly evolving antimicrobial resistance. Despite all the… Click to show full abstract

Antimicrobial resistance is one of the highest priorities in global public health with Staphylococcus aureus among the most important microorganisms due to its rapidly evolving antimicrobial resistance. Despite all the efforts of antimicrobial stewardship, research and development of new antimicrobials are still imperative. The thiazolidine ring is considered a privileged structure for the development of new antimicrobials. This study aimed to compare the antibacterial effects of two analogue series of thiazolidine‐2,4‐dione and 4‐thioxo‐thiazolidin‐2‐one against multidrug‐resistant Staph. aureus clinical isolates.

Keywords: thiazolidin one; thioxo thiazolidin; dione thioxo; thiazolidine dione; staphylococcus aureus; multidrug resistant

Journal Title: Journal of Applied Microbiology
Year Published: 2022

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