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Class 1C antiarrhythmic drugs in atrial fibrillation and coronary artery disease

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Class 1C antiarrhythmic drugs (AADs) are effective first‐line agents for atrial fibrillation (AF) treatment. However, these agents commonly are avoided in patients with known coronary artery disease (CAD), due to… Click to show full abstract

Class 1C antiarrhythmic drugs (AADs) are effective first‐line agents for atrial fibrillation (AF) treatment. However, these agents commonly are avoided in patients with known coronary artery disease (CAD), due to known increased risk in the postmyocardial infarction population. Whether 1C AADs are safe in patients with CAD but without clinical ischemia or infarct is unknown. Reduced coronary flow capacity (CFC) on positron emission tomography (PET) reliably identifies myocardial regions supplied by vessels with CAD causing flow limitation.

Keywords: atrial fibrillation; class antiarrhythmic; coronary artery; antiarrhythmic drugs; artery disease

Journal Title: Journal of Cardiovascular Electrophysiology
Year Published: 2020

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