LAUSR

INTRODUCTION Ablation of atrial fibrillation (AF) with high-power-short-duration (HPSD) radiofrequency (RF) technology is emerging as a new standard of care in many electrophysiology laboratories. While procedural short-term efficacy and efficiency is very promising, little is known about mid- to long-term effects of HPSD ablation for pulmonary vein isolation and left atrial substrate modification. METHODS AND RESULTS In a single-centre registry, 412 AF procedures were performed in 400 individual patients using a standardized CLOSE protocol guided fixed 50W HPSD ablation, aiming for an ablation index (AI) of 400 on the posterior and 550 on the anterior wall. Additional substrate-tailored lines were performed when required. After a mean clinical follow-up of 337 ± 134 days, 15 patients suffered from AF recurrence beyond the blinding period. 12 gave consent to the indicated re-ablation. Here, 11 of 12 patients had chronic isolation of all 4 pulmonary veins (PV). In 3 of 6 patients, a reconnection of additional left atrial ablation lines was revealed. 10 out of 12 patients showed progressive fibrous atrial cardiomyopathy and required additional left atrial substrate modification or re-isolation of left-atrial lines. During the follow-up no clinical case of atrioesophageal fistula was registered. No PV stenosis after initial HPSD PVI was documented. CONCLUSIONS Patients requiring re-ablation of AF or other atrial tachycardia after a fixed 50W HPSD circumferential PVI and substrate modification predominantly suffer from progressive fibrous atrial cardiomyopathy, while PV reconnection appears to be a rare cause of AF recurrence. This article is protected by copyright. All rights reserved.