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Dofetilide suppresses atrial fibrillation (AF) in a dose‐dependent fashion. The protective effect of AF against QTc prolongation induced torsades de pointe and transient post‐cardioversion QTc prolongation may result in dofetilide… Click to show full abstract
Dofetilide suppresses atrial fibrillation (AF) in a dose‐dependent fashion. The protective effect of AF against QTc prolongation induced torsades de pointe and transient post‐cardioversion QTc prolongation may result in dofetilide under‐dosing during initiation. Thus, the optimal timing of cardioversion for AF patients undergoing dofetilide initiation to optimize discharge dose remains unknown as does the longitudinal stability of QTc. The purpose of this study was to evaluate the impact of baseline rhythm on dofetilide dosing during initiation and assess the longitudinal stability of QTc‐all (Bazzett, Fridericia, Framingham, and Hodges) over time.
Journal Title: Journal of Cardiovascular Electrophysiology
Year Published: 2022
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