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FLT3 internal tandem duplication (ITD) mutations are found in around 25% of all acute myeloid leukaemia (AML) cases and is associated with shorter disease‐free and overall survival. Previous reports have… Click to show full abstract
FLT3 internal tandem duplication (ITD) mutations are found in around 25% of all acute myeloid leukaemia (AML) cases and is associated with shorter disease‐free and overall survival. Previous reports have shown that FLT3‐ITD induces a specific phenotype in leukemic blasts, which is characterized by high levels of CD33 and CD123, and that expression of CD33 and CD123 is directly influenced by the DNA FLT3‐ITD/wild‐type FLT3 allelic ratio (AR).
Keywords:
flt3 itd;
itd;
cd123 expression;
cd33 cd123
Journal Title: Journal of Cellular and Molecular Medicine
Year Published: 2020
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Journal Title: Journal of Cellular and Molecular Medicine
Year Published: 2020
Link to full text (if available)
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recommendations!