LAUSR

AIM To examine associations between bone turnover markers (BTMs) and periodontitis in two cross-sectional population-based studies. METHODS AND MATERIALS We used data from two independent adult samples (N = 4993), collected within the Study of Health in Pomerania (SHIP) project, to analyze cross-sectional associations of N-procollagen type 1 amino-terminal propeptide (P1NP), C-terminal cross-linking telopeptide (CTX), osteocalcin, bone specific alkaline phosphatase (BAP), fibroblast growth factor 23 (FGF23), wingless-type mouse mammary tumor virus integration site family member 5a (WNT5A), and sclerostin values with periodontitis. Confounder-adjusted gamma and fractional response regression models were applied. RESULTS Positive associations were found for P1NP with mean PPD (eβ = 1.008; 95% confidence interval (CI): 1.001-1.015), mean CAL (eβ = 1.027; 95% CI: 1.011-1.044) and proportion of sites with BOP (%BOP) (eβ = 1.055; 95% CI: 1.005-1.109). Similar associations showed BAP with %BOP (eβ = 1.121; 95% CI: 1.042-1.205) and proportion of sites with PPD ≥ 4 mm (%PPD4) (eβ = 1.080; 95% CI: 1.005-1.161), and sclerostin with %BOP (eβ = 1.308; 95% CI: 1.005-1.704). WNT5A was inversely associated with mean PPD (eβ = 0.956; 95% CI: 0.920-0.993) and %PPD4 (eβ = 0.794; 95% CI: 0.642-0.982). CONCLUSIONS This study revealed scattered associations of P1NP, BAP, WNT5A, and sclerostin with periodontitis, but the results are contradictory in the overall context. Associations reported in previous studies could not be confirmed. This article is protected by copyright. All rights reserved.