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Several researchers in the statistical and medical communities have noted the overestimation of the treatment effect when a trial is stopped early in the interim analysis for efficacy; however, methods… Click to show full abstract
Several researchers in the statistical and medical communities have noted the overestimation of the treatment effect when a trial is stopped early in the interim analysis for efficacy; however, methods to reduce this overestimation are rarely used because the overestimation mechanisms are not well understood by many in clinical trial practice. A trial design that leads to less overestimation is needed.
Keywords:
overestimation treatment;
interim analysis;
overestimation;
treatment effect
Journal Title: Journal of Clinical Pharmacy and Therapeutics
Year Published: 2019
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Journal Title: Journal of Clinical Pharmacy and Therapeutics
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!