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Population pharmacokinetic study of caffeine citrate in Chinese premature infants with apnea

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Caffeine citrate is a commonly used methylxanthine for pharmacologic treatment of apnea of prematurity. The aim of this study was to develop and verify a population pharmacokinetic (PPK) model, which… Click to show full abstract

Caffeine citrate is a commonly used methylxanthine for pharmacologic treatment of apnea of prematurity. The aim of this study was to develop and verify a population pharmacokinetic (PPK) model, which can provide a reference for individualized caffeine citrate treatment of apnea in Chinese premature infants.

Keywords: citrate; population pharmacokinetic; premature infants; caffeine citrate; chinese premature

Journal Title: Journal of Clinical Pharmacy and Therapeutics
Year Published: 2020

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